Ouabain Decreases Regulatory T Cell Number in Mice by Reducing IL-2 Secretion

Ouabain (OUA) is a cardiotonic glycoside originally extracted from African plants. It has also been described as an endogenous component in mammals, being released in stress situations mainly by the adrenal gland. OUA has been reported to be capable of inhibiting mitogen-induced lymphocyte proliferation and also affects B and T lymphocytes.The aim of this work is to show the effects of OUA in peripheral T lymphocytes.In the in vivo experiments,...