DNA methylation-based estimator of telomere length
Abstract
Telomere length (TL) is associated with several aging-related diseases. Here, we present a DNA methylation estimator of TL (DNAmTL) based on 140 CpGs. Leukocyte DNAmTL is applicable across the entire age spectrum and is more strongly associated with age than measured leukocyte TL (LTL) (r ~-0.75 for DNAmTL versus r ~ -0.35 for LTL). Leukocyte DNAmTL outperforms LTL in predicting: i) time-to-death (p=2.5E-20), ii) time-to-coronary heart disease...
Paper Details
Title
DNA methylation-based estimator of telomere length
Published Date
Aug 18, 2019
Journal
Volume
11
Issue
16
Pages
5895 - 5923
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