PARP-1 activity (PAR) determines the sensitivity of cervical cancer to olaparib
Abstract
Objectives Cervical cancer (CC) remains a major health problem worldwide. Poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors (PARPi) have emerged as a promising class of chemotherapeutics in ovarian cancer. We explored the preclinical in vitro and in vivo activity of olaparib against multiple primary whole exome sequenced (WES) CC cells lines and xenografts. Methods Olaparib cell-cycle, apoptosis,...
Paper Details
Title
PARP-1 activity (PAR) determines the sensitivity of cervical cancer to olaparib
Published Date
Oct 1, 2019
Journal
Volume
155
Issue
1
Pages
144 - 150
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