Inducible T‐cell co‐stimulator: Signaling mechanisms in T follicular helper cells and beyond
Abstract
Human patients with homozygous null mutations in the ICOS gene suffer from recurrent infections due to humoral immune defects. Studies on human patients and mouse models have shown that inducible T-cell co-stimulator (ICOS)-deficient individuals cannot form T follicular helper (Tfh) cells, a group of CD4 T cells that migrate into B cell follicles and facilitate germinal center (GC) reactions. ICOS-induced phosphoinositide 3-kinase signaling...
Paper Details
Title
Inducible T‐cell co‐stimulator: Signaling mechanisms in T follicular helper cells and beyond
Published Date
Aug 12, 2019
Journal
Volume
291
Issue
1
Pages
91 - 103
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