The Role of Volume Regulation and Thermoregulation in AKI during Marathon Running

Marathon runners develop transient AKI with urine sediments and injury biomarkers suggesting nephron damage.To investigate the etiology, we examined volume and thermoregulatory responses as possible mechanisms in runners' AKI using a prospective cohort of runners in the 2017 Hartford Marathon. Vitals, blood, and urine samples were collected in 23 runners 1 day premarathon and immediately and 1 day postmarathon. We measured copeptin at each time...