Polyphenols: Major regulators of key components of DNA damage response in cancer

DNA fidelity is constantly endangered by various types of intrinsic damages and extrinsic damages. Cells that are affected by DNA damage employ a specific, intricate, and interconnected network of cellular and molecular events (known as DNA damage response (DDR)) in order to maintain genome stability. More importantly, DDR is employed to pass intact genomes on to the next generation. Polyphenols constitute a large group of plant-based secondary...