Interplay between Lefty and Nodal signaling is essential for the organizer and axial formation in amphioxus embryos

Volume: 456, Issue: 1, Pages: 63 - 73
Published: Dec 1, 2019
Abstract
The organizer is an essential signaling center required for axial formation during vertebrate embryonic development. In the basal chordate amphioxus, the dorsal blastopore lip of the gastrula has been proposed to be homologous to the vertebrate organizer. Lefty is one of the first genes to be expressed in the organizer. The present results show that Lefty overexpression abolishes the organizer; the embryos were severely ventralized and...
Paper Details
Title
Interplay between Lefty and Nodal signaling is essential for the organizer and axial formation in amphioxus embryos
Published Date
Dec 1, 2019
Volume
456
Issue
1
Pages
63 - 73
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