Enhancer features that drive formation of transcriptional condensates
Abstract
Enhancers are DNA elements that are bound by transcription factors (TFs), which recruit coactivators and the transcriptional machinery to genes. Phase-separated condensates of TFs and coactivators have been implicated in assembling the transcription machinery at particular enhancers, yet the role of DNA sequence in this process has not been explored. We show that DNA sequences encoding TF binding site number, density, and affinity above sharply...
Paper Details
Title
Enhancer features that drive formation of transcriptional condensates
Published Date
Aug 8, 2019
Journal
Volume
75
Issue
3
Pages
549
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