TIMP3 gene polymorphisms and relation to Ankylosing spondylitis susceptibility in Chinese Han population

Background Ankylosing spondylitis (AS) is a type of chronic progressive inflammatory disease, which often causes significant damage to the patients on the physical function, labour ability and quality of life. The study found that the enzyme system tissue inhibitor of matrix metalloproteinases ( TIMPs ) was important for the development of AS. The aim of this study was to investigate the association of polymorphisms of TIMP3 gene with AS in...