In Search of C3G Tissue Biomarkers

See Clinical Research on Page 1387 See Clinical Research on Page 1387 Complement (C) 3 glomerulopathy (C3G) is a rare, complement-mediated disorder that encompasses C3 glomerulonephritis (C3GN) and dense deposit disease (DDD). Drivers can be acquired autoantibodies and/or genetic mutations in distinct components and regulatory factors of the complement alternative pathway (CAP; Figure 1). Most common are autoantibodies, such as the C3 nephritic...