Tachycardia-induced CD44/NOX4 signaling is involved in the development of atrial remodeling
Abstract
Atrial fibrillation (AF) is associated with oxidative stress and Ca2+-handling abnormalities in atrial myocytes. Our prior study has demonstrated the involvement of CD44, a membrane receptor for hyaluronan (HA), in the pathogenesis of AF. This study further evaluated whether CD44 and its related signaling mediate atrial tachycardia-induced oxidative stress and Ca2+-handling abnormalities. Tachypacing in atrium-derived myocytes (HL-1 cell line)...
Paper Details
Title
Tachycardia-induced CD44/NOX4 signaling is involved in the development of atrial remodeling
Published Date
Oct 1, 2019
Volume
135
Pages
67 - 78
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