Sorafenib-Induced Apoptosis in Hepatocellular Carcinoma Is Reversed by SIRT1

Volume: 20, Issue: 16, Pages: 4048 - 4048
Published: Aug 19, 2019
Abstract
Sorafenib is a multi-kinase inhibitor and one of the few systemic treatment options for patients with advanced hepatocellular carcinomas (HCCs). Resistance to sorafenib develops frequently and could be mediated by the nicotinamide adenine dinucleotide (NAD)-dependent deacetylase sirtuin (SIRT)1. We aimed to test whether sorafenib efficacy is influenced by cellular NAD levels and NAD-dependent SIRT1 function. We analyzed sorafenib effects on...
Paper Details
Title
Sorafenib-Induced Apoptosis in Hepatocellular Carcinoma Is Reversed by SIRT1
Published Date
Aug 19, 2019
Volume
20
Issue
16
Pages
4048 - 4048
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