A requirement of Polo-like kinase 1 in murine embryonic myogenesis and adult muscle regeneration
Abstract
Muscle development and regeneration require delicate cell cycle regulation of embryonic myoblasts and adult muscle satellite cells (MuSCs). Through analysis of the Polo-like kinase (Plk) family cell-cycle regulators in mice, we show that Plk1's expression closely mirrors myoblast dynamics during embryonic and postnatal myogenesis. Cell-specific deletion of Plk1 in embryonic myoblasts leads to depletion of myoblasts, developmental failure and...
Paper Details
Title
A requirement of Polo-like kinase 1 in murine embryonic myogenesis and adult muscle regeneration
Published Date
Aug 8, 2019
Journal
Volume
8
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