Plasma Metabolomics to Identify and Stratify Patients With Impaired Glucose Tolerance

Impaired glucose tolerance (IGT) is one of the presymptomatic states of type 2 diabetes mellitus and requires an oral glucose tolerance test (OGTT) for diagnosis. Our aims were twofold: (i) characterize signatures of small molecules predicting the OGTT response and (ii) identify metabolic subgroups of participants with IGT.Plasma samples from 827 participants of the Study of Health in Pomerania free of diabetes were measured using mass...