Plasma cortisol is associated with cerebral hypometabolism across the Alzheimer's disease spectrum

Hypothalamic-pituitary-adrenal dysregulation is proposed as a risk factor for Alzheimer's disease (AD). This study assessed cross-sectional relationships between cortisol and neuroimaging biomarkers of brain structure and glucose metabolism across the AD spectrum. Participants with normal cognition, mild cognitive impairment, and AD were selected from the Alzheimer's Disease Neuroimaging Initiative databank, based on baseline measures of plasma...