Downregulation of kynureninase restrains cutaneous squamous cell carcinoma proliferation and represses the PI3K/AKT pathway

The protein kynureninase (KYNU) has recently been reported to participate in the pathological processes of various diseases.To explore the expression and the biological function of KYNU in cutaneous squamous cell carcinoma (cSCC).Expression of KYNU in cSCC cell lines and tissues was firstly evaluated based on the Gene Expression Omnibus and the Oncomine databases. Quantitative reverse transcription-PCR was performed to determine the mRNA...