Nuclear corepressor SMRT is a strong regulator of body weight independently of its ability to regulate thyroid hormone action
Abstract
Silencing Mediator of Retinoid and Thyroid Hormone Receptors (SMRT) and the nuclear receptor co-repressor1 (NCoR1) are paralogs and regulate nuclear receptor (NR) function through the recruitment of a multiprotein complex that includes histone deacetylase activity. Previous genetic strategies which deleted SMRT in a specific tissue or which altered the interaction between SMRT and NRs have suggested that it may regulate adiposity and insulin...
Paper Details
Title
Nuclear corepressor SMRT is a strong regulator of body weight independently of its ability to regulate thyroid hormone action
Published Date
Aug 12, 2019
Journal
Volume
14
Issue
8
Pages
e0220717 - e0220717
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Notes
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