Computer-aided identification of lung cancer inhibitors through homology modeling and virtual screening

Lung cancer is the most often event cancer around the world and the first leading cause of cancer death in human beings. Rab39a protein is implicated in vesicular trafficking and fusion of phagosomes with lysosomes. Rab39a is overexpressed in lung cancer, which converts normal cells to abnormal cells that reproduce quickly, and resists programmed cell death that usually kills aberrant cells. In the present study, the structure-based drug...