Treatment options for postural instability and gait difficulties in Parkinson’s disease

Introduction: Gait and balance disorders in Parkinson’s disease (PD) represent a major therapeutic challenge as frequent falls and freezing of gait impair quality of life and predict mortality. Limited dopaminergic therapy responses implicate non-dopaminergic mechanisms calling for alternative therapies.Areas covered: The authors provide a review that encompasses pathophysiological changes involved in axial motor impairments in PD,...