CDK4 Regulates Lysosomal Function and mTORC1 Activation to Promote Cancer Cell Survival

Volume: 79, Issue: 20, Pages: 5245 - 5259
Published: Oct 15, 2019
Abstract
Cyclin-dependent kinase 4 (CDK4) is well-known for its role in regulating the cell cycle, however, its role in cancer metabolism, especially mTOR signaling, is undefined. In this study, we established a connection between CDK4 and lysosomes, an emerging metabolic organelle crucial for mTORC1 activation. On the one hand, CDK4 phosphorylated the tumor suppressor folliculin (FLCN), regulating mTORC1 recruitment to the lysosomal surface in response...
Paper Details
Title
CDK4 Regulates Lysosomal Function and mTORC1 Activation to Promote Cancer Cell Survival
Published Date
Oct 15, 2019
Volume
79
Issue
20
Pages
5245 - 5259
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