Evaluation of the usefulness of saliva for DNA methylation analysis in cohort studies

Epigenetic information such as DNA methylation is a useful biomarker that reflects complex gene-environmental interaction. Peripheral tissues such as blood and saliva are commonly collected as the source of genomic DNA in cohort studies. Epigenetic studies mainly use blood, while a few studies have addressed the epigenetic characteristics of saliva.The effects of methods for DNA extraction and purification from saliva on DNA methylation were...