Crude Heparin Preparations Unveil the Presence of Structurally Diverse Oversulfated Contaminants
Abstract
Nowadays, pharmaceutical heparin is purified from porcine and bovine intestinal mucosa. In the past decade there has been an ongoing concern about the safety of heparin, since in 2008, adverse effects associated with the presence of an oversulfated chondroitin sulfate (OSCS) were observed in preparations of pharmaceutical porcine heparin, which led to the death of patients, causing a global public health crisis. However, it has not been...
Paper Details
Title
Crude Heparin Preparations Unveil the Presence of Structurally Diverse Oversulfated Contaminants
Published Date
Aug 17, 2019
Journal
Volume
24
Issue
16
Pages
2988 - 2988
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