Top down or bottom up? An observational investigation of improvement in fibromyalgia symptoms following hip and knee replacement

Objectives Many patients with osteoarthritis have comorbid symptoms of FM, but it is unknown how these symptoms respond to surgical procedures that address nociceptive input in the periphery, such as total joint replacement. Here we explore differences in clinical characteristics between patients whose FM symptoms do and do not improve following total hip or knee replacement. Methods Participants were 150 patients undergoing knee or hip...