The role of GIP and pancreatic GLP-1 in the glucoregulatory effect of DPP-4 inhibition in mice
Abstract
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are two peptides that function to promote insulin secretion. Dipeptidyl peptidase-4 (DPP-4) inhibitors increase the bioavailability of both GLP-1 and GIP but the dogma continues to be that it is the increase in GLP-1 that contributes to the improved glucose homeostasis. We have previously demonstrated that pancreatic rather than intestinal GLP-1 is necessary...
Paper Details
Title
The role of GIP and pancreatic GLP-1 in the glucoregulatory effect of DPP-4 inhibition in mice
Published Date
Aug 14, 2019
Journal
Volume
62
Issue
10
Pages
1928 - 1937
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Notes
History