Preparation of irbesartan composite microparticles by supercritical aerosol solvent extraction system for dissolution enhancement
Abstract
In this study, irbesartan (IST) microparticles, an IST /hydroxypropyl-β-cyclodextrin (HP-β-CD) inclusion complex, and an IST/polyvinylpyrrolidone (PVP) complex were prepared using a supercritical aerosol solvent extraction system (ASES). The goal was to improve the solubility and dissolution rate of IST, which is an angiotensin II receptor blocker and exhibits solubility-limited oral bioavailability in pharmacokinetics. It is noteworthy that...
Paper Details
Title
Preparation of irbesartan composite microparticles by supercritical aerosol solvent extraction system for dissolution enhancement
Published Date
Nov 1, 2019
Volume
153
Pages
104594 - 104594
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