Distinct Molecular Trajectories Converge to Induce Naive Pluripotency
Abstract
Understanding how cell identity transitions occur and whether there are multiple paths between the same beginning and end states are questions of wide interest. Here we show that acquisition of naive pluripotency can follow transcriptionally and mechanistically distinct routes. Starting from post-implantation epiblast stem cells (EpiSCs), one route advances through a mesodermal state prior to naive pluripotency induction, whereas another...
Paper Details
Title
Distinct Molecular Trajectories Converge to Induce Naive Pluripotency
Published Date
Sep 1, 2019
Journal
Volume
25
Issue
3
Pages
388 - 406.e8
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