Myocardial Preconditioning Potential of Hedgehog Activator Purmorphamine (Smoothened Receptor Agonist) against Ischemia-Reperfusion in Deoxycortisone Acetate Salt-Induced Hypertensive Rat Hearts
Volume: 10, Issue: 2, Pages: 47 - 56
Published: Jun 1, 2019
Abstract
Aim: To investigate the myocardial preconditioning potential of hedgehog activator smoothened (SMO) receptor agonist purmorphamine (PUR) against ischemia-reperfusion (I/R) injury in deoxycortisone acetate (DOCA) salt-induced hypertensive rat heart. Methods: Hypertension in rats was produced by surgical removal of the kidney and DOCA salt administration for 6 weeks. Isolated rat heart was subjected to 30 min ischemia followed by 120 min of I/R....
Paper Details
Title
Myocardial Preconditioning Potential of Hedgehog Activator Purmorphamine (Smoothened Receptor Agonist) against Ischemia-Reperfusion in Deoxycortisone Acetate Salt-Induced Hypertensive Rat Hearts
Published Date
Jun 1, 2019
Volume
10
Issue
2
Pages
47 - 56
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