How tenofovir disoproxil fumarate can impact on solubility and dissolution rate of efavirenz?
Abstract
Efavirenz (EFZ) and tenofovir disoproxil fumarate (TDF) can be used simultaneously in the treatment of human immunodeficiency virus type1 infection. In this work the impact of TDF, a hydrophilic drug, on the solubility and dissolution rate of EFZ, a poorly water-soluble drug, was evaluated. EFZ/TDF binary mixtures in different molar ratios were prepared. Differential scanning calorimetry (DSC) results indicate the formation of a eutectic...
Paper Details
Title
How tenofovir disoproxil fumarate can impact on solubility and dissolution rate of efavirenz?
Published Date
Oct 1, 2019
Volume
570
Pages
118597 - 118597
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