Merkel Cell Polyomavirus Small T Antigen Induces DNA Damage Response
Abstract
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine cancer of the skin with high rates of metastasis and mortality. Besides well-established factors including genetic mutations and UV-induced DNA damage in Merkel cell carcinogenesis, the recent discovery of the Merkel cell polyomavirus (MCPyV) has shed light on the viral etiology of MCC. In the current study, we provide novel evidence that MCPyV small T (sT) antigen induces the DNA...
Paper Details
Title
Merkel Cell Polyomavirus Small T Antigen Induces DNA Damage Response
Published Date
Jan 1, 2019
Journal
Volume
62
Issue
2
Pages
96 - 100
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