Myo-inositol alters 13C-labeled fatty acid metabolism in human placental explants

We postulate that myo-inositol, a proposed intervention for gestational diabetes, affects transplacental lipid supply to the fetus. We investigated the effect of myo-inositol on fatty acid processing in human placental explants from uncomplicated pregnancies. Explants were incubated with 13 C-labeled palmitic acid, 13 C-oleic acid and 13 C-docosahexaenoic acid across a range of myo-inositol concentrations for 24 h and 48 h. The incorporation of...