Sex dictates the constitutive expression of hepatic cytochrome P450 isoforms in Göttingen minipigs
Abstract
The cytochrome P450 enzyme (CYP) family includes key enzymes for the metabolism of drugs and xenobiotics. Several animal models have been used to determine the metabolite profile of specific drugs. Among these are porcine microsomes prepared from Göttingen minipigs. However, CYP expression profile in microsomes from this pig breed is unknown. In the present study, we determined the mRNA and protein profiles of a comprehensive selection of CYPs...
Paper Details
Title
Sex dictates the constitutive expression of hepatic cytochrome P450 isoforms in Göttingen minipigs
Published Date
Oct 1, 2019
Journal
Volume
314
Pages
181 - 186
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