Group sequential adaptive designs in series of time-to-event randomised trials in rare diseases: A simulation study
Volume: 29, Issue: 6, Pages: 1483 - 1498
Published: Jul 29, 2019
Abstract
In rare diseases, fully powered large trials may not be doable in a reasonable time frame even with international collaborations. In a previous work, we proposed an approach based on a series of smaller parallel group two-arm randomised controlled trials (RCT) performed over a long research horizon. Within the series of trials, the treatment selected after each trial becomes the control treatment of the next one. We concluded that running more...
Paper Details
Title
Group sequential adaptive designs in series of time-to-event randomised trials in rare diseases: A simulation study
Published Date
Jul 29, 2019
Volume
29
Issue
6
Pages
1483 - 1498
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