Early T Cell Differentiation with Well-Maintained Function across the Adult Life Course in Sub-Saharan Africa

Volume: 203, Issue: 5, Pages: 1160 - 1171
Published: Sep 1, 2019
Abstract
Immune senescence is a significant contributor to health problems in the developed world and may be accelerated by chronic viral infections. To date, there have been few studies of immune function in healthy older people in sub-Saharan Africa. We assessed T cell and B cell phenotypes and immune responses to CMV, EBV, and influenza virus in Malawians aged 20-69 y. Notably, the proportion of naive (CCR7+CD45RA+) CD4 and CD8 T cells was only 14% of...
Paper Details
Title
Early T Cell Differentiation with Well-Maintained Function across the Adult Life Course in Sub-Saharan Africa
Published Date
Sep 1, 2019
Volume
203
Issue
5
Pages
1160 - 1171
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