CrossTalk proposal: The glymphatic system supports convective exchange of cerebrospinal fluid and brain interstitial fluid that is mediated by perivascular aquaporin‐4

The ‘glymphatic’ system is a brain-wide network of perivascular pathways that supports exchange of cerebrospinal fluid (CSF) and brain interstitial fluid (ISF), contributing to the efflux of interstitial solutes including amyloid β (Iliff et al., 2012, 2013a,b). Importantly, this pathway emphasizes a role for astrocytes and the water channel aquaporin-4 (AQP4) in facilitating this exchange, setting it apart from earlier descriptions of...