The Hdl Proteome - Challenges To Analysing Hdl-Associated Proteins And Disentangling Associated Proteins From Contaminating Proteins

Background and Aims: Low HDL-cholesterol (HDL-C) is a major biomarker of both cardiovascular disease (CVD) and the metabolic syndrome but fails to reflect the complexity of HDL particles. We hypothesize that the HDL proteome will reveal much more information, in relation to both diseases. To date, proteomics analysis has been performed on either ultracentrifuged-HDL (UC-HDL) or fast protein liquid chromatography (FPLC)-HDL (FPLC-HDL), with...