Systemic immunization with altered myelin basic protein peptide produces sustained antidepressant-like effects
Abstract
Immune dysregulation, specifically of inflammatory processes, has been linked to behavioral symptoms of depression in both human and rodent studies. Here, we evaluated the antidepressant effects of immunization with altered peptide ligands of myelin basic protein (MBP)-MBP87-99[A91, A96], MBP87-99[A91], and MBP87-99[R91, A96]-in different models of depression and examined the mechanism by which these peptides protect against stress-induced...
Paper Details
Title
Systemic immunization with altered myelin basic protein peptide produces sustained antidepressant-like effects
Published Date
Aug 2, 2019
Journal
Volume
25
Issue
6
Pages
1260 - 1274
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