Pcsk9 9 Induces Vascular Calcification Under Uremic Conditions: In Vitro And In Vivo Study

Background and Aims: Vascular calcification represents a main risk factor of cardiovascular events in patients with chronic kidney disease (CKD). Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) levels correlates with the presence of calcific aortic valve stenosis and carriers of the PCSK9 R46L loss-of-function variant have a low calcific aortic valve stenosis. We investigated a possible role of PCSK9 on aortic...