Functional genetic variants can mediate their regulatory effects through alteration of transcription factor binding.

Volume: 10, Issue: 1, Pages: 3472 - 3472
Published: Aug 2, 2019
Abstract
Functional variants in the genome are usually identified by their association with local gene expression, DNA methylation or chromatin states. DNA sequence motif analysis and chromatin immunoprecipitation studies have provided indirect support for the hypothesis that functional variants alter transcription factor binding to exert their effects. In this study, we provide direct evidence that functional variants can alter transcription factor...
Paper Details
Title
Functional genetic variants can mediate their regulatory effects through alteration of transcription factor binding.
Published Date
Aug 2, 2019
Volume
10
Issue
1
Pages
3472 - 3472
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