Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System
Abstract
Properdin (FP) is a positive regulator of the immune system stimulating the activity of the proteolytically active C3 convertase C3bBb in the alternative pathway of the complement system. Here we present two crystal structures of FP and two structures of convertase bound FP. A structural core formed by three thrombospondin repeats (TSRs) and a TB domain harbors the convertase binding site in FP that mainly interacts with C3b. Stabilization of...
Paper Details
Title
Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System
Published Date
Aug 22, 2019
Journal
Volume
10
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