The expression of genes in top obesity-associated loci is enriched in insula and substantia nigra brain regions involved in addiction and reward

Volume: 44, Issue: 2, Pages: 539 - 543
Published: Aug 6, 2019
Abstract
Genome-wide association studies (GWAS) have identified more than 250 loci associated with body mass index (BMI) and obesity. However, post-GWAS functional genomic investigations have been inadequate for understanding how these genetic loci physiologically impact disease development. We performed a PCR-free expression assay targeting genes located nearby the GWAS-identified SNPs associated with BMI/obesity in a large panel of human tissues....
Paper Details
Title
The expression of genes in top obesity-associated loci is enriched in insula and substantia nigra brain regions involved in addiction and reward
Published Date
Aug 6, 2019
Volume
44
Issue
2
Pages
539 - 543
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