Anti‐incretin effect: The other face of Janus in human glucose homeostasis

Summary The provocative idea that type 2 diabetes (T2D) may be a surgically treated disorder is based on accumulating evidence suggesting impressive remission rates of obesity and diabetes following bariatric surgery interventions. According to the “anti‐incretin” theory, ingestion of food in the gastrointestinal (GI) tract, apart from activating the well‐described incretin effect, also results in the parallel stimulation of a series of negative...