Exome sequencing of Finnish isolates enhances rare-variant association power.

Nature64.80
Volume: 572, Issue: 7769, Pages: 323 - 328
Published: Jul 31, 2019
Abstract
Exome-sequencing studies have generally been underpowered to identify deleterious alleles with a large effect on complex traits as such alleles are mostly rare. Because the population of northern and eastern Finland has expanded considerably and in isolation following a series of bottlenecks, individuals of these populations have numerous deleterious alleles at a relatively high frequency. Here, using exome sequencing of nearly 20,000...
Paper Details
Title
Exome sequencing of Finnish isolates enhances rare-variant association power.
Published Date
Jul 31, 2019
Journal
Volume
572
Issue
7769
Pages
323 - 328
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