Cigarette smoke activates the parthanatos pathway of cell death in human bronchial epithelial cells
Abstract
Tobacco smoke negatively affects human bronchial epithelial (HBE) cells and is directly implicated in the etiology of smoking related respiratory diseases. Smoke exposure causes double-stranded DNA breaks and DNA damage activates PARP-1, the key mediator of the parthanatos pathway of cell death. We hypothesize that smoke exposure activates the parthanatos pathway in HBE cells and represents a cell death mechanism that contributes to smoking...
Paper Details
Title
Cigarette smoke activates the parthanatos pathway of cell death in human bronchial epithelial cells
Published Date
Aug 5, 2019
Journal
Volume
5
Issue
1
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