Arsenic impairs GLUT1 trafficking through the inhibition of the calpain system in lymphocytes
Abstract
Exposure to arsenic is associated with increased risk of developing insulin resistance and type 2 diabetes. The proteases calpain-1 (CAPN1), calpain-2 (CAPN2) and calpain-10 (CAPN10) and their endogenous inhibitor calpastatin (CAST) regulate glucose uptake in skeletal muscle and adipocytes. We investigated whether arsenic disrupts GLUT1 trafficking and function through calpain inhibition, using lymphocytes as a cell model. Lymphocytes from...
Paper Details
Title
Arsenic impairs GLUT1 trafficking through the inhibition of the calpain system in lymphocytes
Published Date
Oct 1, 2019
Volume
380
Pages
114700 - 114700
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