Maternal androgen excess induces cardiac hypertrophy and left ventricular dysfunction in female mice offspring
Abstract
Aims Polycystic ovary syndrome (PCOS) is a common endocrinopathy that is suggested to increase the risk for cardiovascular disease. How PCOS may lead to adverse cardiac outcomes is unclear and here we hypothesized that prenatal exposure to dihydrotestosterone (DHT) and/or maternal obesity in mice induce adverse metabolic and cardiac programming in female offspring that resemble the reproductive features of the syndrome. Methods and results The...
Paper Details
Title
Maternal androgen excess induces cardiac hypertrophy and left ventricular dysfunction in female mice offspring
Published Date
Aug 5, 2019
Journal
Volume
116
Issue
3
Pages
619 - 632
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