Transgenic mice expressing human IL-32 develop adipokine profiles resembling those of obesity-induced metabolic changes
Abstract
Low-grade inflammation is associated with the development of insulin resistance in obese individuals. The present study aims to provide additional evidence strengthening the role of interleukin (IL)-32 in this key process. Using an IL-32 transgenic (IL-32tg) mouse model, we observed that IL-32tg fed a normal diet had greater body weight, due to greater accumulation of white adipose tissue (WAT) along with larger sized adipocytes. This led to...
Paper Details
Title
Transgenic mice expressing human IL-32 develop adipokine profiles resembling those of obesity-induced metabolic changes
Published Date
Jan 1, 2020
Journal
Volume
125
Pages
154793 - 154793
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