Ursodeoxycholic acid for intrahepatic cholestasis in pregnancy

Intrahepatic cholestasis of pregnancy is the most common pregnancy-specific liver disease, with a global incidence of between 0·2% and 2·0%. Intrahepatic cholestasis of pregnancy is characterised by otherwise unexplained pruritus, typically starting in the late second or third trimester of pregnancy, increased serum bile acid concentration or transaminase concentration, or both, and spontaneous relief of symptoms and normalisation of biochemical...