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Prediagnostic Level of Dietary and Urinary Isoflavonoids in Relation to Risk of Liver Cancer in Shanghai, China.

Published on Oct 1, 2019in Cancer Epidemiology, Biomarkers & Prevention5.057
· DOI :10.1158/1055-9965.EPI-18-1075
Wei Zhang36
Estimated H-index: 36
(SJTU: Shanghai Jiao Tong University),
Jing Wang15
Estimated H-index: 15
(SJTU: Shanghai Jiao Tong University)
+ 7 AuthorsYong-Bing Xiang57
Estimated H-index: 57
(SJTU: Shanghai Jiao Tong University)
Abstract
Background: No epidemiological studies have directly assessed the association between dietary and urinary of isoflavonoids and risk of liver cancer in humans. Methods: A nested case-control study including 217 incident cases of liver cancer and 427 individually matched control subjects was conducted in Shanghai, China. Dietary isoflavonoids intakes were assessed through a validated food-frequency questionnaire and the Chinese Food Composition Tables. Urinary excretion levels of four major isoflavonoids were measured by the reversed-phase high-performance liquid chromatography. Odds ratios (ORs) and 95% confidence intervals (CIs) were derived using conditional logistic regression models. Results: The adjusted ORs (95% CIs) for liver cancer across increasing quartiles of urinary genistein levels were 1.00 (reference), 0.55 (95% CI = 0.22 to 1.36), 0.57 (95% CI = 0.23 to1.43) and 0.19 (95% CI = 0.06 to 0.59) (P=0.008 for trend) in women and 1.00 (reference), 1.22(0.52,2.86), 1.17(0.47,2.90), 1.23 (0.55-2.76) in men, respectively. These associations were consistent by limiting the cases to primary malignant neoplasm of liver or malignant neoplasms of the intrahepatic bile ducts, or among participants without self-reported liver disease or cirrhosis at the baseline survey. No associations were found between dietary isoflavonoids and liver cancer risk. Conclusions: Our study suggests for the first time that urinary excretion of genistein may be associated with reduced risk of liver cancer in women. Impact: In this nested case-control study in China, we found that urinary excretion of genistein was associated with lower risk of liver cancer in women, and not in men.
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References24
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The Shanghai Men’s Health Study (SMHS) is a population-based cohort study of 61 480 men aged 40–74 years, launched in 2002 in urban Shanghai to investigate the contribution of lifestyle/environmental factors and genetic susceptibility to cancer and other non-communicable diseases (NCDs). At baseline, trained interviewers collected detailed information on personal and dietary habits, occupational/medical history and physical activity, and took anthropometric measurements (response rate: 74%). Blo...
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Background Genistein (Gen) exhibits anti-mutagenic and anti-metastatic activities in hepatoma cell lines. Gen has suppressive effects on tumor growth and angiogenesis in nude mice. Gen suppresses the enzymatic activity of matrix metalloproteinase (MMP)-9; however, the mechanism underlying its anti-invasive activity on hepatocellular carcinoma (HCC) cells is unclear.
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Although dietary patterns, specific foods, and their constituents have been linked to cancer risk, the role of dietary patterns and specific food groups in liver cancer risk has not been investigated. In the Shanghai Women’s Health Study (SWHS) and Shanghai Men’s Health Study (SMHS), two cohort studies of 132 837 Chinese women and men, we evaluated the relationship between dietary patterns, food groups, and liver cancer risk. Through in-person interviews, dietary information intake over the prec...
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