A protein scaffold, engineered SPINK2, for generation of inhibitors with high affinity and specificity against target proteases
Abstract
Proteases are one of attractive therapeutic targets to play key roles in pharmacological action. There are many protease inhibitors in nature, and most of them structurally have cystine knot motifs. Their structures are favorable for recognition of active pockets of proteases, leading to the potent inhibition. However, they also have drawbacks, such as broad cross-reactivity, on the therapeutic application. To create therapeutic proteins derived...
Paper Details
Title
A protein scaffold, engineered SPINK2, for generation of inhibitors with high affinity and specificity against target proteases
Published Date
Aug 7, 2019
Journal
Volume
9
Issue
1
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