Polygenic and clinical risk scores and their impact on age at onset of cardiometabolic diseases and common cancers

Abstract
Background Polygenic risk scores (PRS) have shown promise in predicting susceptibility to common diseases. However, the extent to which PRS and clinical risk factors act jointly and identify high-risk individuals for early onset of disease is unknown. Methods We used large-scale biobank data (the FinnGen study; n=135,300), with up to 46 years of prospective follow-up, and the FINRISK study with standardized clinical risk factor measurements to...
Paper Details
Title
Polygenic and clinical risk scores and their impact on age at onset of cardiometabolic diseases and common cancers
Published Date
Aug 6, 2019
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